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Following the Wheat Belly lifestyle of wheat and grain elimination results in weight loss in the majority of people in short order.

But there are exceptions. The exceptions should not be interpreted to mean that this lifestyle does not work; it should initiate a search for why the weight loss effect of wheat and grain elimination is being blocked. Iodine deficiency, for example, is a common cause for failed weight loss, no matter how perfect your diet and how much you exercise.

Another common cause for failed weight loss are prescription drugs and a few over-the-counter drugs. Among the common drugs that will block your ability to lose weight, even allowing weight gain, are:

  • Beta blockers—metoprolol, atenolol, carvedilol, and propranolol
  • Antidepressants—amitryptiline (Elavil), nortryptyline (Pamelor), doxepin, paroxetine (Paxil), and trazodone, and others
  • Steroids such as prednisone
  • Antihistamines—diphenhydramine (Benadryl), fexofenadine (Allegra), cetirizine (Zyrtec), cyproheptadine (Periactin) and others
  • Lyrica for fibromyalgia and pain
  • Valproic acid (Depakote) for seizures
  • Actos and Avandia for pre-diabetes and diabetes
  • Insulin—Injectable insulin can be responsible not just for failed weight loss, but astounding quantities of weight gain.

Drugs as common as antihistamines for allergies, or beta blockers for high blood pressure, will therefore completely booby-trap any effort at weight loss. The problem is not the diet; the problem is that you are exposed to a drug that blocks the physiologic capacity to lose weight. The solution is therefore not reducing calories, or more exercise, or going back to grains, but to get rid of the drug.

Note that many of these drugs were prescribed to treat conditions that were caused or worsened by wheat and grain consumption. It is therefore worth having a serious discussion with your healthcare provider about stopping or reducing your reliance on these drugs. Some drugs, such as beta blockers, cannot be stopped safely, but need to be reduced gradually to avoid a potentially dangerous withdrawal process. If your doctor refuses to discuss this issue, or is ignorant, find one who will discuss this important issue with you.

More discussions about factors that account for failed weight loss can be found in Wheat Belly Total Health.