Practitioners in the aesthetics industry are experts in practices such as microneedling, red light therapy, filler injections, and retinoids, i.e., strategies introduced to skin externally. Most of these methods exert their effects on the epidermis, some (via limited epidermal penetration or injection) act at the dermal level. And such practices do indeed yield limited benefits in skin smoothness, reduction in wrinkle depth, increased moisture.

But what if you could improve the results you achieve by addressing skin health from within? What if you could cause fibroblasts in skin to produce more collagen and thereby thicken the dermal layer, restoring it to its former youthfulness? What if you could increase hyaluronic acid content of the dermis, thereby retaining more moisture? What if you could protect skin from sun damage and reverse existing damage by providing protective factors in skin, not topically, but from within by, for instance, inhibiting the activity of matrix metalloproteinase enzymes that degrade collagen?

Apply a hyaluronic acid serum or a topical retinoid around the eyes and the prominence of crow’s feet around the eyes can be reduced. But will this improve skin health and appearance on the hands, neck, or thighs? Will it improve joint health, heart health, or gastrointestinal health? No, of course not. Topical agents can only exert their effects locally at the site of application.

Take hyaluronic orally, however, and you can improve skin body-wide. You also increase joint lubrication (synovial fluid that is composed mostly of hyaluronic acid), heart and arterial health (arteries are lined with hyaluronic acid), and gastrointestinal health (since hyaluronic acid acts as a fiber that nourishes microbes in the gut). One of the wonderful effects of ingesting hyaluronic acid orally is that gastrointestinal microbes convert it to the fatty acid, butyrate, that migrates to the skin and reduces pH, or acidifies, the skin, inhibiting the growth of unhealthy microbes such as Staphylococcus aureus that plague people with itchiness, irritation, redness, eczema, seborrhea, psoriasis, rosacea and other skin conditions. Topical hyaluronic acid achieves none of this.

And what if there are also benefits on shape and body composition such as reduced abdominal fat and restoration of youthful musculature, benefits on bone density and cardiovascular health? Of course, topical agents cannot achieve any of these effects.

All of this is achievable with oral agents. Such powerful effects achievable through oral means do not replace your external efforts, but make them more effective: greater reduction of wrinkles, greater “plumping,” greater glow, more youthful elasticity. And benefits on skin are not only at the site of topical application, but body-wide.

Aestheticians and estheticians can therefore achieve significantly improved skin health and appearance benefits for their clients by adding oral agents—not only hyaluronic acid, but also collagen peptides, carotenoids such as astaxanthin, and restoring the microbe lost from the gastrointestinal microbiomes of nearly all modern people, Lactobacillus reuteri, responsible for boosting release of oxytocin from the brain that thereby dramatically increases dermal collagen and by reducing endotoxemia that is a powerful skin irritant. This is part of the emerging and exciting world of nutricosmetics, restoring factors absent or lacking in modern life that, when restored, yield spectacular skin benefits. This is what we are trying to achieve with Oxiceutics.