Nejman 2020

Efforts to pinpoint the causes for various cancers have been sought over the years: smoking and lung cancer, estrogen and endometrial cancer, lack of fiber and colon cancer. But there is a factor that leads not to just one form of cancer, but many: LPS endotoxemia.

In a fascinating study conducted by an Israeli research group, 1500 cancerous tumors that were surgically removed were examined for the presence of both bacteria and lipopolysaccharide (LPS) endotoxin. Recall that LPS endotoxin is a component of the cell walls of fecal microbes, Proteobacteria or Gram negative species such as E. coli, Salmonella, and Campylobacter. These are also the species that dominate in colonic dysbiosis and in small intestinal bacterial overgrowth, SIBO.

Look at the above “heatmap” graphic from this study showing that a high percentage of melanoma, ovary, glioblastoma (GBM), and breast cancers contain LPS, lesser quantities in lung and bone cancers. (Not shown is the absence of LPS in normal tissues from healthy volunteers and in non-cancerous tissues. The increased “LTA” in melanoma represents lipoteichoic acid, the counterpart of LPS in Gram-positive microbes.) The presence of LPS in these cancers is consistent with other evidence showing that LPS is a driving factor in cancers that include:

You can appreciate why I call LPS the “uber risk factor” for cancer.

We know with confidence that LPS is a potent driver of inflammation when it enters the bloodstream. Colonic dysbiosis and SIBO are situations involving inflammation of the intestinal lining and increased intestinal permeability, allowing higher levels of LPS to become blood borne and take up residence in breast, liver, and other tissues where it provokes an inflammatory response in those sites, as well. It is not yet known for most cancers, however, whether LPS is an initiating cause or simply makes the cancer grow and metastasize once it becomes established. Beyond LPS endotoxin, a number of bacterial species themselves were recovered from cancer sites in this and other studies, species such as Fusobacterium nucleatum in colon cancer, H. pylori in stomach cancer, Enterobacter species in pancreatic cancer. It is becoming clear that microbes and their toxic compounds such as LPS are major factors in cancer.

Most interestingly, informed management of the microbiome, especially the gastrointestinal microbiome, is likely to yield reduced cancer risk. While no one yet has performed a study demonstrating, for instance, that eradication of SIBO and thereby endotoxemia results in a reduction in cancer incidence, you could readily predict that this will likely be the case. And, now that we have SIBO Yogurt, i.e., a combination of three microbial species/strains that 1) colonize the small intestine and colon, and 2) produce bacteriocins, natural antibiotics effective against Proteobacteria fecal microbes, a benign but powerful strategy, I believe I can make the argument that, by adopting this strategy, you have likely reduced your risk of multiple forms of cancers. And, of course, you do so while enjoying greater empathy and generosity, smoother skin, return of youthful muscle, preservation of bone density, acceleration of health, an amplified immune response, and increased libido.